(R&D) In vitro Assay Development Research Assistant

We are looking for a highly motivated and creative candidate to join our in vitro drug discovery team in Geneva. You will participate to the design and hands-on implementation of new biological assays, to help us identify the binding sites and modes of action of small therapeutic molecules (allosteric modulators) targeting GPCRs. You will contribute to the discovery of novel allosteric modulators and to the identification of clinical candidates, that address human conditions with high unmet medical need. We expect you to be self-driven, a strong team player, with excellent organisational and communication skills.

Description of the Work

•    browse the literature, build knowledge around the therapeutic target of interest

•    plan experimental concepts & implement them

•    design fusion proteins, suitable for cellular signalling using FRET/BRET approaches

•    generate mammalian cell lines expressing the assay system

•    experimentally characterize binding, and biological activity of allosteric modulators

•    analyse & document results, provide pharmacological interpretations

•    prepare presentations, suggest follow-up experiments

•    use software tools to analyse mode of action of our compounds on a molecular level

•    supervise the work of interns in our team  

Required skills

•    Masters’ degree (or equivalent), in Molecular and Cellular Biology, Biochemistry, Pharmacology, Neuroscience, Live Science Engineering, or in a related field  

•    demonstrated previous experience (1-2 years) in assay development, receptor pharmacology, cellular signalling

•    experience in using software packages to model and interpret complex data will be considered an asset

•    experience in general cell-culture techniques and DNA engineering

•    knowledge of molecular and cell biology, biochemistry, biophysics, organic chemistry

•    high degree of independence, eagerness to take on an own project.

•    proactive mindset, combined with excellent communication, reporting and documentation skills

•    attention to detail, and flexibility are essential

•    ability to work efficiently and flexibly in a small team.

•    basic IT: Microsoft Office. GraphPad, Pymol, etc... is a plus

•    good working knowledge of English and/or French

•    Swiss Nationality or eligible for Swiss work permit

Post-doctoral candidates will not be considered for this position