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PhD fellow in Prenatal programming of disease. HOVEDSTADEN

Empleo de Profesores de universidades y de la enseñanza superior en Dinamarca (HOVEDSTADEN)

Clasificación del trabajo: Profesionales científicos e intelectuales : Profesionales de la enseñanza : Profesores de universidades y de la enseñanza superior : Profesores de universidades y de la enseñanza superior.

Arbejde, der forudsætter viden på højeste niveau inden for pågældende område : Undervisning og pædagogisk arbejde : Undervisning og forskning ved universiteter og højere læreranstalter : Undervisning og forskning på universiteter og højere læreranstalter

Descripción de la oferta de trabajo:

PhD fellow in Prenatal programming of disease Department of Biology Faculty of Science University of Copenhagen Department of Biology, Faculty of Science at University of Copenhagen is offering a PhD scholarship in of prenatal programming of disease, specifically focused on how stress transfers between mother and fetus through pregnancy, commencing 1.09.2018 or as soon as possible thereafter. Description of the scientific environment The project is a collaboration between the Sandelin group at Bioinformatics Centre, Department of Biology and BRIC, and the Sørig Hougaard group at National Research Centre for the Working Environment (NFA).

The Sandelin group is a high-profile joint computational/experimental group focusing on gene regulation and transcriptomics.

The Bioinformatics Centre employs around 50 researchers, and has many international connections to high-profile groups.

The groups are housed in the Biocenter in central Copenhagen, Denmark.

The Sørig Hougaard group at NFA group is focused on toxicology, working environment and in particular effects of particles and stress on reproduction and development.

NFA is located within biking distance of the Biocenter. Project description This project will characterize how acute stress induced in pregnant mothers transfers from mother to fetus and the molecular signalling molecules and regulators that underlie this process.

This will be done through a time series analysis in pregnant mice using on RNA and protein levels, coupled to state of the art computational analysis, and parallel investigations of signalling molecules in blood.

The project will employ one experimental PhD student and one computational postdoc, working as a team together with dedicated technicians.

The successful candidate will work both at the Biocenter, University of Copenhagen and at NFA, and is also expected to make at least one longer stay at proteomics collaborators abroad. Previous papers by Sandelin and Sørig Hougard groups: Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.

Boyd et al., Nature Communications 2018 2018; 9: 1661.

Identification of Gene Transcription Start Sites and Enhancers Responding to Pulmonary Carbon Nanotube Exposure in Vivo.

Bornholdt et al, ACS Nano.

2017;11(4):3597-3613 Chronic maternal inflammation or high fat feeding programs offspring obesity in a sex-dependent manner.

Int J Obesity 2017 41(9):1420-1426.

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters.

Chen et al.

Nat Genet.

2016 48(9):984-94.

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Arner et al, Science.

2015 347(6225):1010-4.

A perspective on the developmental toxicity of nanoparticles.

Hougaard et al.

Reproductive Toxicology 2015 56:118-40.

An atlas of active enhancers across human cell types and tissues.

Andersson et al.

Nature.

2014 507(7493):455-461 Principal supervisor is Professor Albin Sandelin, Department of Biology and BRIC, albinbinf.ku.dk, Direct Phone: +45 35 32 12 85.

Secondary supervisor is Associate prof.

Karin Sørig Hougaard at NFA: KSHnfa.dk, +45 3916 5217 Job description The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:

  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months, abroad
  • Work for the department
Formal requirements Applicants must hold an MSc degree in a life science field (e.g. biology, molecular biomedicine, etc) with excellent results.

Although the work focus will be

Servicio de empleo de origen: AMS, Servicios Públicos de Empleo, Dinamarca.

País del trabajo: Dinamarca.

Región: Hovedstaden.

Ver 681 ofertas de trabajo en "HOVEDSTADEN" (Dinamarca).

Fecha de inicio: 01/06/2018.

Nº de vacantes: 1.

Nivel educativo requerido: Sin especificar.

Cómo solicitar el puesto: Henriette H. Bak-Jensen

Empresa: KU - SCIENCE - BIO.

Contacto: Britt Størk-Hansen

Ver las 445 ofertas de trabajo de Profesionales científicos e intelectuales : Profesionales de la enseñanza : Profesores de universidades y de la enseñanza superior : Profesores de universidades y de la enseñanza superior ofertadas.

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