Biologist - Microbiology (m/f/d) (Biologe/Biologin)

Stellenangebotsbeschreibung:

Become a member of the BioNTech Family!

As a part of our team of more than 5.000 pioneers, you will play a key role in developing solutions for some of the most crucial scientific challenges of our age. Within less than a year, we were able to develop our COVID-19 mRNA vaccine following the highest scientific and ethical standards - writing medical history.

BioNTech R&D Austria is a wholly owned subsidiary of BioNTech SE, focused on the development of novel antibacterial drugs to treat persistent bacterial infections. Our development programs are based on our proprietary LysinBuilder platform, which allows the targeted development of synthetic lysins for virtually any bacterial pathogen. We use a combination of randomized directed evolution approaches and rational in-silico engineering, coupled to high-throughput screening, to generate artificial lysins and develop them into drugs. The development pipeline focuses on chronic bacterial infections where antibiotics fail to cure or destroy the natural microbiomes. Our lead asset is BNT331, which we develop for the treatment of bacterial vaginosis. We also work on transforming the standard of care with lysins against several other infections and dysbioses.

Research Associate* - Microbiology

As Research Associate* at BioNTech R&D Austria you will join our research team and help us bring next generation drugs from the bench into the clinic.

Within the scope of your assignment, autonomously execute series of experiments to support the developmental program, all following established protocols and in accordance with general guidelines and instructions, including:

Activity testing of lysins against bacterial strains (BSL-2 strains like Gardnerella, others)

Biofilm assays

Isolation of bacteria from human and environmental samples

Characterization of endolysins (e.g. MIC, lysis kinetic, surface staining)

Analysis of ex vivo samples (e.g. PK measurements by ELISA, qPCR)

Actively participate in designing the required experiments and improving the established protocols, as part of the lab team

If necessary, develop capabilities in operating advanced equipment, including programming of a pipetting robot and flow cytometer as well as documentation methods

Documentation of results according to the internal quality standards (near-GLP), to ensure the quality of the documentation meets the expectation of the authorities regarding a marketing authorization for a pharmaceutical

Maintain laboratory infrastructure, including purchasing of reagents and equipment, and constantly making materials like media and agar plates available, documenting and maintaining the inventory of biological materials

At least 6 months research experience in at least one of the following areas:

Completed university degree (BSc. or MSc.) in microbiology, infection biology or a related subject or vocational training as lab technician (this position is not suitable for candidates with a PhD)

At least 1 year of (cumulative) laboratory experience during internships or work experience. Extensive laboratory or biotech experience is a plus and will be reflected in the compensation package

Microbiological assays (biofilms, MIC assays, killing assays, etc.), preferably involving proteins

ELISA, Flow cytometry, Microscopy, qPCR

Detection, isolation and typing of bacteria from human samples

Interest in targeted pharmaceutical development and working in a team of highly skilled and motivated professionals

Fluent in English

Become part of developing a new drug class in anti-infectives

Take responsibility for specific parts of the development program and work together with highly experienced researchers in executing the development plan

Pioneer new methods and processes to industrialize key research techniques

Be part of a highly motivated, multinational and fun team that believes synthetic lysins can be part of the solution to the global antibiotics crisis

A competitiv...